My mom had an extremely high tolerance, higher than anyone I know, but she was experiencing pain for about three weeks, to the point where even she knew there was something wrong.  However, the doctors kept giving her regular pain medication and couldn't figure out what it was.  They couldn't figure out what was wrong with her because they overlooked symptoms of heart disease.  My mom died a week after her last doctors appointment (October 4, 2009) due to a blood clot that broke off in her heart and blocked a vein.  I lost my mom when I was 20, and she was 48, because a doctor overlooked symptoms because she was a female.